Description

6-Fluoro-3-Hydroxy-4-Indazolecarboxylic Acid is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique indazole core, functionalized with fluorine, hydroxyl, and carboxylic acid groups, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and anti-cancer agent discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the bioactivity of the fluorinated indazole structure.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials and advanced polymers due to its rigid, functionalized aromatic system.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags and molecular probes in diagnostic and biochemical research.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise, multi-functional heterocycles.

Basic Information

Product Name	6-Fluoro-3-Hydroxy-4-Indazolecarboxylic Acid
CAS No.	885521-93-7
Molecular Formula	C8H5FN2O3
Molecular Weight	196.14 g/mol
Synonyms	4-Indazolecarboxylic acid, 6-fluoro-3-hydroxy-; 6-Fluoro-3-hydroxy-1H-indazole-4-carboxylic acid; 6-Fluoro-3-hydroxyindazole-4-carboxylic acid; 3-Hydroxy-6-fluoro-1H-indazole-4-carboxylic acid; 6-Fluoro-3-hydroxy-4-carboxyindazole; 6-Fluoro-3-hydroxy-4-indazole carboxylic acid; 885521-93-7; 6-Fluoro-3-hydroxyindazole-4-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 6-Fluoro-3-Hydroxy-4-Indazolecarboxylic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical intermediate grade meets stringent internal specifications, with purity typically exceeding 97% (HPLC). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, residual solvents, and heavy metals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.