Description

5,6,7,8-Tetrahydro-[1,8]Naphthyridine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate belonging to the naphthyridine class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its rigid, bicyclic scaffold which is instrumental in the design and synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of therapeutic agents, particularly for applications in oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Used in the production of active pharmaceutical ingredients (APIs) targeting specific biological pathways.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and receptor interactions.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Item	Details
Product Name	5,6,7,8-Tetrahydro-[1,8]Naphthyridine-2-Carboxylic Acid
CAS No.	885278-22-8
Molecular Formula	C9H10N2O2
Molecular Weight	178.19 g/mol
Synonyms	5,6,7,8-Tetrahydro-1,8-naphthyridine-2-carboxylic acid; 2-Carboxy-5,6,7,8-tetrahydro-1,8-naphthyridine; THNCA; Tetrahydro[1,8]naphthyridine-2-carboxylic acid; 1,8-Naphthyridine-2-carboxylic acid, 5,6,7,8-tetrahydro-; 5,6,7,8-Tetrahydro-1,8-naphthyridin-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5,6,7,8-Tetrahydro-[1,8]Naphthyridine-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and commercial projects with material produced under quality systems designed to meet cGMP and ISO standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product should be kept under an inert atmosphere for long-term storage to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.