Description

2-(4-Bromo-Phenyl)-4-Chloro-7-Fluoro-Quinazoline is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core quinazoline scaffold, substituted with halogen atoms (bromine, chlorine, fluorine) at strategic positions, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other biologically active molecules for oncology and other therapeutic areas.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides, leveraging its halogenated quinazoline structure.
• Material Science: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Academic & Contract Research: Essential for medicinal chemistry programs, structure-activity relationship (SAR) studies, and method development in synthetic chemistry.
• Custom Synthesis: A starting material for the contract manufacturing of complex, proprietary compounds for various industrial applications.

Basic Information

Product Name	2-(4-Bromo-Phenyl)-4-Chloro-7-Fluoro-Quinazoline
CAS No.	885277-86-1
Molecular Formula	C14H7BrClFN2
Molecular Weight	352.57 g/mol
Synonyms	4-Chloro-7-fluoro-2-(4-bromophenyl)quinazoline; 2-(4-Bromophenyl)-4-chloro-7-fluoroquinazoline; 7-Fluoro-4-chloro-2-(4-bromophenyl)quinazoline; Quinazoline, 2-(4-bromophenyl)-4-chloro-7-fluoro-; 885277-86-1; 4-Chloro-7-fluoro-2-(p-bromophenyl)quinazoline; 2-(p-Bromophenyl)-4-chloro-7-fluoroquinazoline
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Bromo-Phenyl)-4-Chloro-7-Fluoro-Quinazoline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, identity confirmation (NMR, IR, MS), and residual solvent analysis to ensure the material meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.