Description

4-Chloro-2-(2-Fluoro-Phenyl)-5-Methyl-Quinazoline is a high-purity, advanced pharmaceutical intermediate with a defined heterocyclic structure. This compound matters for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the global pharmaceutical and agrochemical industries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted small-molecule drugs, especially kinase inhibitors and other receptor antagonists.
• Agrochemical Research: Used in developing new active ingredients for crop protection products, leveraging its quinazoline core.
• Chemical Biology & Proteomics: Serves as a scaffold or a tagged molecule for studying protein-ligand interactions and enzyme functions.
• Material Science Research: Investigated as an organic component for advanced materials, such as organic semiconductors or metal-organic frameworks (MOFs).
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process optimization for client projects.

Basic Information

Product Name	4-Chloro-2-(2-Fluoro-Phenyl)-5-Methyl-Quinazoline
CAS No.	885277-61-2
Molecular Formula	C15H10ClFN2
Molecular Weight	272.71 g/mol
Synonyms	4-Chloro-2-(2-fluorophenyl)-5-methylquinazoline; 2-(2-Fluorophenyl)-4-chloro-5-methylquinazoline; 5-Methyl-4-chloro-2-(2-fluorophenyl)quinazoline; Quinazoline, 4-chloro-2-(2-fluorophenyl)-5-methyl-; 885277-61-2; 4-Chloro-2-(o-fluorophenyl)-5-methylquinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(2-Fluoro-Phenyl)-5-Methyl-Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.