Description

5-(Trifluoromethyl)-1H-Indazole is a high-value fluorinated indazole derivative, a crucial heterocyclic building block in modern synthetic chemistry. Its core value lies in the unique combination of the indazole scaffold and the electron-withdrawing trifluoromethyl group, which is instrumental in modulating the physicochemical and biological properties of target molecules. This compound is primarily sought after by pharmaceutical, agrochemical, and advanced materials research and development sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and oncology research programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the CF₃ group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for organic electronic materials, such as ligands for OLEDs or charge-transport materials, due to its electron-deficient aromatic system.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing chemical probes and inhibitors to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences industry with tailored, complex molecules.

Basic Information

Product Name	5-(Trifluoromethyl)-1H-Indazole
CAS No.	885271-64-7
Molecular Formula	C₈H₅F₃N₂
Molecular Weight	186.14 g/mol
Synonyms	5-(Trifluoromethyl)-1H-indazole; 1H-Indazole, 5-(trifluoromethyl)-; 5-Trifluoromethylindazole; 5-Trifluoromethyl-1H-indazole; 5-CF3-1H-Indazole; 5-(Trifluoromethyl)indazole; 885271-64-7
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-1H-Indazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and MS confirmation, to meet the stringent requirements of research and development. A Certificate of Analysis (COA) is supplied with each batch and is available for review upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.