Description

5-Bromo-3-Iodo-Imidazo[1,2-A]Pyridine-2-Carboxylic Acid Ethyl Ester is a high-value, multi-halogenated heterocyclic building block crucial for modern pharmaceutical and agrochemical research. This compound matters because its unique imidazopyridine scaffold, functionalized with bromine and iodine atoms, provides versatile sites for further cross-coupling reactions, enabling the rapid synthesis of complex molecular libraries. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for creating novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas like oncology and CNS disorders.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in developing new active ingredients for crop protection products, leveraging its halogenated structure for bioactivity.
• Chemical Biology Probe Development: Employed in creating molecular probes for studying enzyme function and biological pathways due to its modifiable halogen handles.
• Material Science: Acts as a building block for advanced organic electronic materials and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The bromine and iodine substituents make it an excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions.
• Library Synthesis for High-Throughput Screening: Used in parallel and combinatorial chemistry to generate diverse compound sets for biological screening.

Basic Information

Item	Details
Product Name	5-Bromo-3-Iodo-Imidazo[1,2-A]Pyridine-2-Carboxylic Acid Ethyl Ester
CAS No.	885271-42-1
Molecular Formula	C10H7BrIN2O2
Molecular Weight	408.98 g/mol
Synonyms	Ethyl 5-Bromo-3-iodoimidazo[1,2-a]pyridine-2-carboxylate; 5-Bromo-3-iodoimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester; Imidazo[1,2-a]pyridine-2-carboxylic acid, 5-bromo-3-iodo-, ethyl ester; 885271-42-1; AI3-52353; AKOS040759623; BRN 12521047; CS-0426136; SCHEMBL21804027; ZINC000253909777
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Iodo-Imidazo[1,2-A]Pyridine-2-Carboxylic Acid Ethyl Ester is produced under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.