Description

4-Chloro-2-(Piperazin-1-Yl)-6-(Trifluoromethyl)Quinoline is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinoline core substituted with a piperazine ring, a chloro group, and a trifluoromethyl moiety. This compound is of significant commercial value for its role as a key building block in the synthesis of novel, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in the areas of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially kinase inhibitors and receptor antagonists.
• Medicinal Chemistry Research: Used extensively in research and development (R&D) for structure-activity relationship (SAR) studies and lead optimization programs.
• Active Pharmaceutical Ingredient (API) Development: A key starting material (KSM) or intermediate in the development pathway of new Active Pharmaceutical Ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to contract research organizations and contract manufacturing organizations for custom synthesis and scale-up projects.
• Chemical Biology Probes: Utilized in the creation of chemical probes for studying specific biological pathways and target validation.

Basic Information

Product Name	4-Chloro-2-(Piperazin-1-Yl)-6-(Trifluoromethyl)Quinoline
CAS No.	885270-52-0
Molecular Formula	C14H13ClF3N3
Molecular Weight	315.72 g/mol
Synonyms	4-Chloro-2-(1-piperazinyl)-6-(trifluoromethyl)quinoline; 6-(Trifluoromethyl)-4-chloro-2-(piperazin-1-yl)quinoline; 4-Chloro-6-(trifluoromethyl)-2-(1-piperazinyl)quinoline; 2-(Piperazin-1-yl)-4-chloro-6-(trifluoromethyl)quinoline; 885270-52-0; Quinoline, 4-chloro-2-(1-piperazinyl)-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(Piperazin-1-Yl)-6-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be stored away from light. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.