Description

5-(2-Bromophenyl)Thieno[2,3-D]Pyrimidin-4-Amine is a high-purity organic building block and pharmaceutical intermediate of significant commercial and research interest. This compound, with CAS number 885269-55-6, is valued for its heterocyclic structure, which incorporates both thienopyrimidine and brominated phenyl motifs, making it a versatile scaffold in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly kinase inhibitors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule drugs, especially for oncology and inflammatory disease research.
• Kinase Inhibitor Scaffold: Serves as a core structural element for designing and optimizing potent and selective kinase inhibitors due to its thienopyrimidine pharmacophore.
• Chemical Biology Research: Used as a molecular probe to study enzyme function and signal transduction pathways in academic and industrial R&D settings.
• High-Throughput Screening (HTS): Employed in compound libraries for screening against novel biological targets to identify hit compounds.
• Structure-Activity Relationship (SAR) Studies: The bromophenyl moiety provides a handle for further functionalization, enabling detailed SAR exploration to enhance drug-like properties.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects requiring complex heterocycles.

Basic Information

Product Name	5-(2-Bromophenyl)Thieno[2,3-D]Pyrimidin-4-Amine
CAS No.	885269-55-6
Molecular Formula	C12H8BrN3S
Molecular Weight	306.18 g/mol
Synonyms	5-(2-Bromophenyl)-4-aminothieno[2,3-d]pyrimidine; 4-Amino-5-(2-bromophenyl)thieno[2,3-d]pyrimidine; Thieno[2,3-d]pyrimidin-4-amine, 5-(2-bromophenyl)-; 885269-55-6; 5-(2-Bromophenyl)-4-thieno[2,3-d]pyrimidinamine; 5-(o-Bromophenyl)thieno[2,3-d]pyrimidin-4-amine; 5-(2-Bromophenyl)-4-aminothienopyrimidine
EINECS	Contact for details

Quality Control

Our 5-(2-Bromophenyl)Thieno[2,3-D]Pyrimidin-4-Amine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for pharmaceutical research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management systems to support our commitment to supply reliability and product integrity for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials and sources of ignition. For long-term storage, consider storage under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.