Description

2-Nitro-3,4-Difluoro Bromobenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique combination of nitro, bromo, and difluoro substituents on the benzene ring makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as cross-coupling reactions and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in constructing fluorinated and halogenated aromatic cores for bioactive molecules.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides where the difluoro and nitro groups contribute to biological activity and environmental stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its halogenated aromatic structure.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for metal-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig aminations, enabling rapid diversification.
• Chemical Derivatization: The nitro group can be readily reduced to an amine, providing a versatile pathway to anilines and further functionalized compounds.
• Fluorine Chemistry Studies: Acts as a model substrate for investigating the effects of ortho-fluorine substitution on aromatic reactivity and electronic properties.

Basic Information

Product Name	2-Nitro-3,4-Difluoro Bromobenzene
CAS No.	884495-47-0
Molecular Formula	C6H2BrF2NO2
Molecular Weight	237.99 g/mol
Synonyms	1-Bromo-2-nitro-3,4-difluorobenzene; 3,4-Difluoro-2-nitro-1-bromobenzene; 2-Nitro-3,4-difluorophenyl bromide; Benzene, 1-bromo-2-nitro-3,4-difluoro-; 884495-47-0; 2-Nitro-3,4-difluorobromobenzene
EINECS	Contact for details

Quality Control

Our 2-Nitro-3,4-Difluoro Bromobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container must be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.