Description

(1S,3Ar,7Ar)-1-((S)-1-(3-Hydroxy-3-Methylbutoxy)Ethyl)-7A-Methylhexahydro-1H-Inden-4(2H)-One is a high-purity, stereochemically defined synthetic intermediate of significant importance in advanced pharmaceutical synthesis. This compound is valued for its complex, rigid indane-based structure which serves as a crucial chiral building block for the development of novel therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex small molecule drugs, particularly those targeting metabolic and inflammatory pathways.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of proprietary active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization campaigns.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Synthesis of Steroid Mimetics: Its fused ring system makes it valuable for constructing non-steroidal frameworks that mimic biological activity.
• Asymmetric Synthesis: Utilized in catalytic asymmetric transformations to introduce multiple stereocenters with high fidelity.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	(1S,3Ar,7Ar)-1-((S)-1-(3-Hydroxy-3-Methylbutoxy)Ethyl)-7A-Methylhexahydro-1H-Inden-4(2H)-One
CAS No.	884488-07-7
Molecular Formula	C18H32O3
Molecular Weight	296.45 g/mol
Synonyms	7a-Methyl-1-[(1S)-1-[(3S)-3-hydroxy-3-methylbutoxy]ethyl]octahydro-1H-inden-4-one; (1S,3aR,7aR)-1-[(1S)-1-[(3S)-3-Hydroxy-3-methylbutoxy]ethyl]-7a-methyloctahydro-1H-inden-4-one; (4S,4aR,9aR)-4-[(1S)-1-[(3S)-3-Hydroxy-3-methylbutoxy]ethyl]-4a,9-dimethyl-1,2,3,4,4a,5,6,9a-octahydronaphthalen-7-one; A key intermediate for PF-05190457; Indanone derivative intermediate; Chiral indanone ether alcohol.
EINECS	Contact for details

Quality Control

Our (1S,3Ar,7Ar)-1-((S)-1-(3-Hydroxy-3-Methylbutoxy)Ethyl)-7A-Methylhexahydro-1H-Inden-4(2H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess and NMR for structural confirmation, to ensure high chemical and isomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.