Description

(6',7'-Dichloro-2'-Oxospiro[1,3-Dioxane-2,3'-Indol]-1'(2'H)-Yl)Acetonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic indole structure. This compound is of significant value for its role as a key building block in the synthesis of novel, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry and drug discovery programs, particularly those targeting central nervous system and oncological pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those with spirocyclic or fused heterocyclic architectures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) in academic and industrial R&D labs.
• API Development: Used in the process development and scale-up of Active Pharmaceutical Ingredients (APIs) requiring this specific molecular framework.
• Biochemical Probe Synthesis: Employed to create specialized probes and tool compounds for investigating biological targets and mechanisms of action.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	(6',7'-Dichloro-2'-Oxospiro[1,3-Dioxane-2,3'-Indol]-1'(2'H)-Yl)Acetonitrile
CAS No.	883649-19-2
Molecular Formula	C14H10Cl2N2O3
Molecular Weight	325.15 g/mol
Synonyms	1-(Cyanomethyl)-6,7-dichloro-1,2-dihydrospiro[3H-indole-3,2'-[1,3]dioxane]-2-one; 6,7-Dichloro-1-(cyanomethyl)-1,2-dihydrospiro[3H-indole-3,2'-[1,3]dioxan]-2-one; (6,7-Dichloro-2-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl)acetonitrile; Spiro[1,3-dioxane-2,3'-indole]-1'(2'H)-acetonitrile, 6',7'-dichloro-2'-oxo-; CAS 883649-19-2
EINECS	Contact for details

Quality Control

Our (6',7'-Dichloro-2'-Oxospiro[1,3-Dioxane-2,3'-Indol]-1'(2'H)-Yl)Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere if possible. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.