Description

2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid is a high-value, multi-functional organic building block that combines a carboxylic acid group with a boronic ester pinacol group on a fluorinated aromatic ring. This compound matters for its critical role as a key intermediate in modern synthetic chemistry, enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. Pharmaceutical, agrochemical, and advanced materials researchers need it for the efficient synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials where the fluorine substituent and benzoic acid moiety are essential for tuning biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing fluorinated drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the fluorine atom enhances bioactivity and environmental stability.
• Material Science: Serves as a monomer or precursor for creating specialty polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester functionality makes it a stable and highly reactive partner for palladium-catalyzed coupling with various aryl/heteroaryl halides.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the construction of bifunctional molecules for targeted protein degradation research.
• Fluorine-Containing Compound Library Synthesis: Essential for medicinal chemistry programs focused on creating diverse compound libraries to explore structure-activity relationships (SAR).

Basic Information

Product Name	2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoic Acid
CAS No.	882679-10-9
Molecular Formula	C₁₃H₁₆BFO₄
Molecular Weight	266.08 g/mol
Synonyms	5-Carboxy-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; 2-Fluoro-5-(pinacolboryl)benzoic acid; Benzoic acid, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluorobenzoic acid; 2-Fluoro-5-borono-benzoic acid, pinacol ester; 882679-10-9; 2-Fluoro-5-(pinacolatoboryl)benzoic acid
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for each shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture and atmospheric oxygen, which can affect the stability of the boronic ester moiety.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.