Description

6-Bromo-2-Chloroquinazoline CAS NO 882672-05-1 is a high-purity halogenated quinazoline derivative, a crucial building block in advanced organic synthesis. Its bifunctional halogen handles make it an indispensable intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, anticancer agents, and other biologically active quinazoline-based compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, leveraging the quinazoline scaffold's bioactivity.
• Material Science Research: Serves as a building block for organic semiconductors, liquid crystals, and photoactive materials due to its aromatic, planar structure.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Cross-Coupling Reactions: The bromo and chloro substituents are orthogonal reactive sites for sequential Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Library Synthesis for Drug Discovery: Enables rapid parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening (HTS).

Basic Information

Product Name	6-Bromo-2-Chloroquinazoline
CAS No.	882672-05-1
Molecular Formula	C8H4BrClN2
Molecular Weight	243.49 g/mol
Synonyms	2-Chloro-6-bromoquinazoline; 6-Bromo-2-chloro-quinazoline; Quinazoline, 6-bromo-2-chloro-; BR-882672-05-1; 882672-05-1; 6-Bromo-2-chlor-chinazolin; 6-Brom-2-chlorchinazolin
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-Chloroquinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee batch-to-batch consistency and traceability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.