Description

(3-Methyl-3H-Diazirin-3-Yl)Methanamine Hydrochloride is a specialized diazirine-based chemical building block, primarily valued for its role as a photoactivatable crosslinking agent in advanced biochemical research. This compound matters because it enables the study of protein-protein interactions and biomolecular structures through efficient, light-induced covalent bonding. It is essential for researchers and manufacturers in the fields of chemical biology, proteomics, and pharmaceutical development who require precise tools for affinity labeling and mapping biological pathways.

Application

• Photoaffinity Labeling (PAL): A critical reagent for crosslinking and identifying transient or weak interactions between proteins, peptides, and small molecule ligands upon UV light activation.
• Proteomics Research: Used to "trap" and study protein complexes in their native state, facilitating the mapping of interactomes and signaling networks.
• Drug Discovery: Employed in target identification and validation studies to elucidate the binding sites and mechanisms of action of novel drug candidates.
• Bioconjugation: Serves as a versatile linker for attaching probes, tags, or other molecules to biomolecules for detection, purification, or imaging applications.
• Material Science: Applied in surface functionalization and the creation of smart polymeric materials where light-controlled crosslinking is required.

Basic Information

Product Name	(3-Methyl-3H-Diazirin-3-Yl)Methanamine Hydrochloride
CAS No.	882516-45-2
Molecular Formula	C4H9N3•HCl
Molecular Weight	135.59 g/mol (Free base: 99.14 g/mol)
Synonyms	3-(Aminomethyl)-3-methyldiazirine Hydrochloride; 3-Methyl-3-(aminomethyl)diazirine Hydrochloride; 3-Methyl-3H-diazirin-3-ylmethanamine Hydrochloride; Diazirine-amine HCl; Photoaffinity Labeling Amine Reagent; PAL Amine HCl; Light-Activated Crosslinker Amine
EINECS	Contact for details

Quality Control

Our (3-Methyl-3H-Diazirin-3-Yl)Methanamine Hydrochloride is produced under strict quality protocols to ensure high purity and batch-to-batch consistency, which is critical for reproducible research results. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Handle in a well-ventilated area using appropriate personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.