Description

3',6'-Dihydro-1-Methyl-Spiro[3H-Indole-3,2'-[2H]Pyran]-2(1H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic indole-pyran fused ring structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with potential biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor for novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery projects.
• Organic Synthesis Building Block: Employed in the construction of complex heterocyclic frameworks due to its spirocyclic architecture.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological mechanisms and target validation.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and scale-up services under GMP or non-GMP conditions.

Basic Information

Product Name	3',6'-Dihydro-1-Methyl-Spiro[3H-Indole-3,2'-[2H]Pyran]-2(1H)-One
CAS No.	882041-44-3
Molecular Formula	C14H15NO2
Molecular Weight	229.27 g/mol
Synonyms	1-Methylspiro[indoline-3,2'-pyran]-2-one; Spiro[indoline-3,2'-pyran]-2-one, 1-methyl-; 1-Methyl-1'H-spiro[indoline-3,2'-pyran]-2-one; 1-Methylspiro[3H-indole-3,2'-[2H]pyran]-2(1H)-one; 882041-44-3; 3',6'-Dihydro-1-methylspiro[3H-indole-3,2'-[2H]pyran]-2(1H)-one
EINECS	Contact for details

Quality Control

Our 3',6'-Dihydro-1-Methyl-Spiro[3H-Indole-3,2'-[2H]Pyran]-2(1H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. For customers requiring specific regulatory documentation, we offer support for DMF filings and can tailor quality protocols to meet project-specific needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.