Description

4,5-Difluoro-2,3-Dihydro-2,2-Dimethyl-1H-Inden-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique indanone core structure with strategic fluorine substitutions. This compound matters for its critical role as a key building block in the synthesis of complex, biologically active molecules, offering significant value in modern medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for therapeutic areas where fluorinated compounds provide enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a specialized building block for constructing complex molecular scaffolds in drug discovery and lead optimization programs.
• Fluorinated Compound Synthesis: Exploited for introducing the 4,5-difluoro motif into target molecules to modulate their physicochemical and pharmacokinetic properties.
• Agrochemical Research: Potential application as an intermediate in the development of new fluorinated pesticides or herbicides, where the difluoro group can influence biological activity.
• Material Science Precursor: Can be utilized in the research and development of advanced organic materials, such as ligands for catalysts or components for organic electronics.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	4,5-Difluoro-2,3-Dihydro-2,2-Dimethyl-1H-Inden-1-One
CAS No.	881189-87-3
Molecular Formula	C11H10F2O
Molecular Weight	196.19 g/mol
Synonyms	4,5-Difluoro-2,2-dimethyl-2,3-dihydro-1H-inden-1-one; 2,3-Dihydro-4,5-difluoro-2,2-dimethyl-1H-inden-1-one; 1H-Inden-1-one, 4,5-difluoro-2,3-dihydro-2,2-dimethyl-; 4,5-Difluoro-2,2-dimethylindan-1-one; Difluoro Dimethyl Dihydroindenone; 881189-87-3; CAS 881189-87-3
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2,3-Dihydro-2,2-Dimethyl-1H-Inden-1-One is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical applications. Each lot undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support our clients' regulatory needs and can supply material that meets the stringent requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.