Description

5',6',7',8'-Tetrahydro-3'H-Spiro[Cyclohexane-1,4'-Quinazoline]-2'-Thiol is a sophisticated spirocyclic quinazoline derivative, a high-value chemical intermediate prized for its unique molecular architecture. This compound matters for its role as a critical building block in advanced pharmaceutical research and fine chemical synthesis, enabling the development of novel active ingredients. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create new molecules with targeted properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing spirocyclic pharmacophores.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging the structural complexity for novel modes of action.
• Chemical Biology Probe: Acts as a scaffold or functionalized intermediate for creating tool compounds to study biological pathways and enzyme functions.
• Ligand Synthesis for Catalysis: The thiol and heterocyclic nitrogen atoms make it a candidate for constructing novel ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Investigated as a monomer or building block for advanced polymers and organic electronic materials due to its rigid, three-dimensional structure.

Basic Information

Product Name	5',6',7',8'-Tetrahydro-3'H-Spiro[Cyclohexane-1,4'-Quinazoline]-2'-Thiol
CAS No.	879361-72-5
Molecular Formula	C₁₄H₂₀N₂S
Molecular Weight	248.39 g/mol
Synonyms	3'H-Spiro[cyclohexane-1,4'-quinazoline]-2'-thiol, 5',6',7',8'-tetrahydro-; 2'-Mercapto-5',6',7',8'-tetrahydrospiro[cyclohexane-1,4'-quinazoline]; Spiro[cyclohexane-1,4'-quinazoline]-2'-thiol, 5',6',7',8'-tetrahydro-3'H-; Tetrahydrospiro[cyclohexane-1,4'-quinazoline]-2'-thiol; 879361-72-5; CAS 879361-72-5
EINECS	Contact for details

Quality Control

Our 5',6',7',8'-Tetrahydro-3'H-Spiro[Cyclohexane-1,4'-Quinazoline]-2'-Thiol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to minimize potential oxidation of the thiol group. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.