Description

5-(4-Methoxy-Phenyl)-4-Methyl-Thiophene-2-Carboxylic Acid CAS NO 878680-51-4 is a high-purity, advanced pharmaceutical intermediate characterized by its distinct thiophene-carboxylic acid structure. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in synthetic chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Organic Synthesis Reagent: Used in research-scale and process chemistry for constructing complex thiophene-containing molecular architectures via coupling, condensation, and functional group transformation reactions.
• Agrochemical Research: Serves as a precursor in the development of new crop protection agents and herbicides that leverage its specific heterocyclic core.
• Material Science: Potential monomer or precursor for specialty polymers and organic electronic materials due to the conjugated thiophene system.
• Academic & Contract Research: Essential compound for universities and CROs (Contract Research Organizations) conducting studies in medicinal chemistry and synthetic methodology.

Basic Information

Product Name	5-(4-Methoxy-Phenyl)-4-Methyl-Thiophene-2-Carboxylic Acid
CAS No.	878680-51-4
Molecular Formula	C13H12O3S
Molecular Weight	248.30 g/mol
Synonyms	5-(4-Methoxyphenyl)-4-methylthiophene-2-carboxylic acid; 4-Methyl-5-(4-methoxyphenyl)thiophene-2-carboxylic acid; 2-Thiophenecarboxylic acid, 5-(4-methoxyphenyl)-4-methyl-; 878680-51-4; 5-(p-Methoxyphenyl)-4-methyl-2-thiophenecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5-(4-Methoxy-Phenyl)-4-Methyl-Thiophene-2-Carboxylic Acid adheres to stringent quality management protocols. Each batch is analyzed using advanced chromatographic and spectroscopic techniques to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, residual solvents, and related substances are provided with every shipment. We support compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.