Description

tert-Butyl 5-Methylspiro[Indoline-3,4'-Piperidine]-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Serves as a critical scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities.
• API Development: Used in the research, development, and scale-up production of novel Active Pharmaceutical Ingredients (APIs).
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for custom synthesis projects.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	tert-Butyl 5-Methylspiro[Indoline-3,4'-Piperidine]-1-Carboxylate
CAS No.	878376-82-0
Molecular Formula	C18H26N2O2
Molecular Weight	302.41 g/mol
Synonyms	1-Boc-5-Methylspiro[indoline-3,4'-piperidine]; 5-Methyl-1,3-dihydrospiro[indene-2,4'-piperidine]-1-carboxylic acid tert-butyl ester; 1-N-Boc-5-methylspiro[indoline-3,4'-piperidine]; tert-Butyl 5-methyl-1,3-dihydro-2H-spiro[indole-3,4'-piperidine]-1-carboxylate; 5-Methylspiro[indoline-3,4'-piperidine]-1-carboxylic acid tert-butyl ester; Spiro[indoline-3,4'-piperidine]-1-carboxylic acid, 5-methyl-, 1,1-dimethylethyl ester; 878376-82-0
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 5-Methylspiro[Indoline-3,4'-Piperidine]-1-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We are committed to meeting the exacting standards required for pharmaceutical R&D and can provide material in various grades, including research and GMP-grade, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.