Description

5,6,7,8-Tetrahydro-1,6-Naphthyridine-2-Carboxylate is a high-purity, heterocyclic organic compound that serves as a critical advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high structural specificity. This product is essential for research and development chemists and process scale-up teams within the global pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon in the research and commercial synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• API Synthesis: Used as a core structural motif for constructing complex molecules in the final stages of Active Pharmaceutical Ingredient (API) manufacturing.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of new chemical entities in drug discovery pipelines.
• Agrochemical Development: Serves as a building block for creating new crop protection agents and herbicides with specific modes of action.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialty chemicals with high added value.
• Ligand and Catalyst Development: Potential utility in the design of novel ligands for catalytic systems or metal-organic frameworks (MOFs).

Basic Information

Product Name	5,6,7,8-Tetrahydro-1,6-Naphthyridine-2-Carboxylate
CAS No.	877861-62-6
Molecular Formula	C10H12N2O2
Molecular Weight	192.22 g/mol
Synonyms	1,6-Naphthyridine-2-carboxylic acid, 5,6,7,8-tetrahydro-; Ethyl 5,6,7,8-tetrahydro-1,6-naphthyridine-2-carboxylate (common salt form); THN-2C; 5,6,7,8-Tetrahydro-1,6-naphthyridin-2-yl carboxylate; 2-Carboxy-5,6,7,8-tetrahydro-1,6-naphthyridine; 877861-62-6; Tetrahydro-naphthyridine carboxylate intermediate
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydro-1,6-Naphthyridine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and residual solvents is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.