Description

(5Z)-1-(1,1-Dioxothiolan-3-Yl)-5-(Furan-2-Ylmethylidene)-4-Methyl-2,6-Dioxopyridine-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a specialized building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in research targeting specific therapeutic pathways. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of proprietary drug candidates, especially in oncology and anti-inflammatory research.
• Chemical Research & Development: Used as a sophisticated scaffold for exploring new chemical spaces and structure-activity relationships (SAR) in medicinal chemistry programs.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and the development of new synthetic methodologies.
• Process Chemistry Optimization: Utilized for scaling up synthetic routes from milligram to kilogram scale, supporting process development and optimization studies.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development, quality control, and impurity profiling in API manufacturing.

Basic Information

Item	Details
Product Name	(5Z)-1-(1,1-Dioxothiolan-3-Yl)-5-(Furan-2-Ylmethylidene)-4-Methyl-2,6-Dioxopyridine-3-Carbonitrile
CAS No.	877795-44-3
Molecular Formula	C17H12N2O5S
Molecular Weight	356.36 g/mol
Synonyms	1-(1,1-Dioxothiolan-3-yl)-5-[(2-furyl)methylidene]-4-methyl-2,6-dioxo-3-pyridinecarbonitrile; (5Z)-5-(Furan-2-ylmethylene)-1-(1,1-dioxothiolan-3-yl)-4-methyl-2,6-dioxo-1,2,3,6-tetrahydropyridine-3-carbonitrile; 877795-44-3; 5-(Furan-2-ylmethylidene)-1-(sulfolane-3-yl)-4-methyl-2,6-dioxo-1,2,3,6-tetrahydropyridine-3-carbonitrile; 3-Cyano-1-(1,1-dioxothiolan-3-yl)-5-(furan-2-ylmethylidene)-4-methylpyridine-2,6-dione
EINECS	Contact for details

Quality Control

Our (5Z)-1-(1,1-Dioxothiolan-3-Yl)-5-(Furan-2-Ylmethylidene)-4-Methyl-2,6-Dioxopyridine-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.