Description

1'-(3,4-Dimethoxybenzyl)Spiro[1,3-Dioxane-2,3'-Indol]-2'(1'H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic indole-dioxane structure. This compound is critical for enabling complex synthetic routes in modern drug discovery, offering a versatile scaffold for the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of bioactive molecules targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly those with spirocyclic architectures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in academic and industrial R&D labs.
• API Development: Used in the development and scale-up processes for Active Pharmaceutical Ingredients (APIs) with complex heterocyclic cores.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological targets and signaling pathways.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	1'-(3,4-Dimethoxybenzyl)Spiro[1,3-Dioxane-2,3'-Indol]-2'(1'H)-One
CAS No.	876890-51-6
Molecular Formula	C21H21NO5
Molecular Weight	367.40 g/mol
Synonyms	1'-(3,4-Dimethoxybenzyl)spiro[1,3-dioxane-2,3'-indolin]-2'-one; Spiro[1,3-dioxane-2,3'-indole]-2'(1'H)-one, 1'-(3,4-dimethoxybenzyl)-; 876890-51-6; 1'-(3,4-Dimethoxybenzyl)-2'-oxospiro[1,3-dioxane-2,3'-indoline]; (3,4-Dimethoxybenzyl)spiro[1,3-dioxane-2,3'-indolin]-2'-one
EINECS	Contact for details

Quality Control

Our production of 1'-(3,4-Dimethoxybenzyl)Spiro[1,3-Dioxane-2,3'-Indol]-2'(1'H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and commercial projects with custom synthesis and scale-up capabilities, ensuring a reliable supply of material that meets your specific project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.