Description

(E)-n-(4-(3-Chloro-4-(Pyridin-2-Ylmethoxy)Phenylamino)-3-Cyano-7-Ethoxyquinolin-6-Yl)-4-(Dimethylamino)But-2-Enamide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure designed for targeted therapeutic applications. Its molecular architecture makes it a critical building block in the synthesis of novel kinase inhibitors, particularly for oncology research and development. This compound is essential for pharmaceutical manufacturers and advanced research institutions focused on developing next-generation small molecule therapeutics. The CAS number for this compound is 876310-02-0.

Application

This specialized quinoline derivative serves as a key intermediate in several high-value chemical synthesis pathways. Its primary and related applications include:

• Pharmaceutical Intermediate: Core building block for the synthesis of potent and selective kinase inhibitors used in cancer research.
• Oncology Drug Discovery: Used in medicinal chemistry programs targeting specific protein kinases involved in cell proliferation and survival pathways.
• Biochemical Research: Serves as a reference standard and a tool compound for in vitro biological activity assays and mechanism-of-action studies.
• Preclinical Development: Employed in the scale-up synthesis of candidate drugs for pharmacokinetic and toxicology evaluations.
• Custom Synthesis: A starting material for the preparation of structurally analogous compounds for structure-activity relationship (SAR) exploration.

Basic Information

Product Name	(E)-n-(4-(3-Chloro-4-(Pyridin-2-Ylmethoxy)Phenylamino)-3-Cyano-7-Ethoxyquinolin-6-Yl)-4-(Dimethylamino)But-2-Enamide
CAS No.	876310-02-0
Molecular Formula	C₃₀H₂₉ClN₆O₃
Molecular Weight	557.05 g/mol
Synonyms	Lapatinib Intermediate; (E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide; Tykerb Intermediate; GW572016 Intermediate; N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)-2-butenamide; (E)-N-(4-(3-Chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and purity suitable for pharmaceutical development. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all critical quality attributes are provided with each shipment. We support development under cGMP guidelines as required for API synthesis.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. For long-term stability, storage at 2-8°C is recommended. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.