Description

(R)-1-(4-Methylbenzyl)Pyrrolidin-3-Aminedihydrochloride is a high-purity chiral amine derivative, supplied as a dihydrochloride salt to enhance stability and handling. This compound serves as a critical pharmaceutical intermediate and chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals. It is essential for research and manufacturing organizations in the pharmaceutical, agrochemical, and specialty chemical sectors requiring enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Utilized as a chiral ligand or auxiliary in catalytic asymmetric reactions to induce stereoselectivity.
• Agrochemical Research: Serves as a building block for the synthesis of enantiomerically pure pesticides and herbicides.
• Chemical Biology & Proteomics: Used in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	(R)-1-(4-Methylbenzyl)Pyrrolidin-3-Aminedihydrochloride
CAS No.	876159-30-7
Molecular Formula	C12H20N2 • 2HCl
Molecular Weight	273.22 g/mol (Free base: 200.30 g/mol)
Synonyms	(R)-1-(4-Methylbenzyl)-3-aminopyrrolidine dihydrochloride; (R)-1-(p-Tolylmethyl)-3-aminopyrrolidine dihydrochloride; (3R)-1-[(4-Methylphenyl)methyl]-3-pyrrolidinamine dihydrochloride; (R)-1-(4-Methylbenzyl)-3-pyrrolidinamine dihydrochloride; (R)-1-(p-Methylbenzyl)-3-aminopyrrolidine dihydrochloride; (R)-1-(4-Methylbenzyl)pyrrolidin-3-amine dihydrochloride; (R)-3-Amino-1-(4-methylbenzyl)pyrrolidine dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-(4-Methylbenzyl)Pyrrolidin-3-Aminedihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.