Description

(R)-1-(4-Fluorobenzyl)Pyrrolidin-3-Aminedihydrochloride is a high-purity chiral amine derivative, primarily utilized as a critical pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, especially those targeting neurological receptors.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the research and development of new chemical entities (NCEs).
• Asymmetric Synthesis: Used in catalytic and stoichiometric asymmetric reactions to introduce chirality into target molecules.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.
• Preclinical & Clinical Trial Material: Sourced for the production of batches required for non-clinical studies and early-phase clinical trials.

Basic Information

Product Name	(R)-1-(4-Fluorobenzyl)Pyrrolidin-3-Aminedihydrochloride
CAS No.	876159-29-4
Molecular Formula	C11H16FN2·2HCl
Molecular Weight	279.18 g/mol
Synonyms	(R)-1-[(4-Fluorophenyl)methyl]-3-pyrrolidinamine dihydrochloride; (3R)-1-[(4-Fluorophenyl)methyl]-3-pyrrolidinamine dihydrochloride; (R)-1-(4-Fluorobenzyl)-3-aminopyrrolidine dihydrochloride; (R)-1-(4-Fluorobenzyl)pyrrolidin-3-amine dihydrochloride; (R)-1-(4-Fluorobenzyl)-3-pyrrolidinamine dihydrochloride; (R)-1-(4-Fluorobenzyl)-3-aminopyrrolidine dihydrochloride salt; (R)-1-(4-Fluorobenzyl)pyrrolidin-3-amine HCl salt
EINECS	Contact for details

Quality Control

Our (R)-1-(4-Fluorobenzyl)Pyrrolidin-3-Aminedihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.