Description

1H-Thieno[3,4-D]Imidazole-4-Pentanamide, Hexahydro-2-Oxo-n-3,6,9,12-Tetraoxatetradec-1-Yl-, (3As,4S,6Ar)- is a sophisticated, high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound matters because its unique molecular architecture, featuring a thienoimidazole core linked to a polyether chain, makes it a valuable precursor for constructing complex active pharmaceutical ingredients (APIs) and novel chemical entities. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries working on innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel therapeutic agents, particularly those targeting complex biological pathways.
• Bioconjugation & Linker Chemistry: The polyether chain (3,6,9,12-tetraoxatetradec-1-yl) moiety serves as a potential hydrophilic spacer or linker in antibody-drug conjugates (ADCs) and prodrug design.
• Medicinal Chemistry Research: Used to explore structure-activity relationships (SAR) in drug discovery projects, especially for compounds requiring heterocyclic and solubilizing elements.
• Process Chemistry Development: Serves as a critical intermediate for scaling up the production of candidate drugs from milligram to kilogram scale under GMP conditions.
• Chemical Biology Probes: Can be utilized to create specialized molecular probes for studying enzyme function or cellular processes.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, complex organic molecules.

Basic Information

Product Name	1H-Thieno[3,4-D]Imidazole-4-Pentanamide, Hexahydro-2-Oxo-n-3,6,9,12-Tetraoxatetradec-1-Yl-, (3As,4S,6Ar)-
CAS No.	875773-88-9
Molecular Formula	C20H31N3O7S
Molecular Weight	457.54 g/mol
Synonyms	(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide, N-3,6,9,12-tetraoxatetradec-1-yl-; Biotin-PEG4-amine derivative; Biotinylated tetraethylene glycol amine; Biotin-PEG4-NH2 (related structural analog); 1H-Thieno[3,4-d]imidazol-4-pentanamide, hexahydro-2-oxo-N-(3,6,9,12-tetraoxatetradec-1-yl)-, (3aS,4S,6aR)-; PEG4-Biotin Amine; Amine-PEG4-Biotin; N-(13-Amino-4,7,10-trioxatridec-1-yl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
EINECS	Contact for details

Quality Control

Our 1H-Thieno[3,4-D]Imidazole-4-Pentanamide, Hexahydro-2-Oxo-n-3,6,9,12-Tetraoxatetradec-1-Yl-, (3As,4S,6Ar)- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere at lower temperatures (e.g., -20°C) to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.