Description

(2R)-2-Fluoromethylpyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound matters for its role in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including potential treatments for neurological disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Asymmetric Synthesis: Serves as a valuable precursor for constructing molecules with defined stereochemistry.
• Ligand and Catalyst Development: Potential use in the development of chiral ligands for catalytic processes.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological systems.

Basic Information

Product Name	(2R)-2-Fluoromethylpyrrolidine Hydrochloride
CAS No.	875553-78-9
Molecular Formula	C5H11FN • HCl
Molecular Weight	139.61 (Free base) / 176.06 (HCl salt)
Synonyms	(R)-2-(Fluoromethyl)pyrrolidine hydrochloride; (2R)-2-(Fluoromethyl)-1-azacyclopentane hydrochloride; (R)-2-Fluoromethylpyrrolidine HCl; Pyrrolidine, 2-(fluoromethyl)-, (2R)-, hydrochloride; 875553-78-9; (R)-2-Fluoromethylpyrrolidine hydrochloride; (2R)-2-Fluoromethylpyrrolidine HCl salt
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is characterized to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) are available upon request, detailing specifications such as assay, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere or in a controlled environment to prevent moisture uptake. Long-term storage at 2-8°C is advised for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.