Description

3-Bromo-1-Fluoro-2-Iodonaphthalene is a high-purity, multi-halogenated naphthalene derivative, serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a valuable precursor for constructing complex molecular architectures, particularly in the development of pharmaceuticals and functional materials. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise and reliable halogenated intermediates for cross-coupling reactions and structure-activity relationship studies.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex polycyclic aromatic systems.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides by providing a versatile halogenated aromatic core.
• Material Science: Serves as a precursor for organic semiconductors, liquid crystals, and other functional organic materials due to its electron-deficient aromatic structure.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi coupling reactions, enabling the formation of new carbon-carbon bonds.
• Chemical Synthesis: Utilized in medicinal chemistry for lead optimization and in academic research for exploring new synthetic methodologies.
• Ligand & Catalyst Development: Can be functionalized to create novel ligands for metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	3-Bromo-1-Fluoro-2-Iodonaphthalene
CAS No.	874907-48-9
Molecular Formula	C₁₀H₅BrFI
Molecular Weight	350.95 g/mol
Synonyms	1-Fluoro-3-bromo-2-iodonaphthalene; 2-Iodo-3-bromo-1-fluoronaphthalene; 3-Bromo-1-fluoro-2-iodonaphthalene; Naphthalene, 3-bromo-1-fluoro-2-iodo-; 874907-48-9; 3-Br-1-F-2-I-Naphthalene
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-1-Fluoro-2-Iodonaphthalene is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality assurance ensures reliability for your most sensitive R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate to prevent degradation. Keep away from strong acids/bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.