Description

(6Ar,10Ar)-3-(6-Imidazol-1-Yl-2-Methylhexan-2-Yl)-6,6,9-Trimethyl-6A,7,10,10A-Tetrahydrobenzo[C]Chromen-1-Ol:Hydrochloride CAS NO 874745-43-4 is a high-purity synthetic cannabinoid receptor ligand, specifically formulated as a hydrochloride salt for enhanced stability and handling. This compound is of significant interest for advanced pharmacological research and development, particularly in the study of the endocannabinoid system. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers focused on neuroscience and therapeutic discovery.

Application

• Pharmacological Reference Standard: Serves as a critical analytical standard for method development and quality control in cannabinoid research.
• Neuroscience Research: Used in in vitro and in vivo studies to investigate cannabinoid receptor (CB1/CB2) binding affinity, signaling pathways, and physiological effects.
• Drug Discovery & Development: A key intermediate or active pharmaceutical ingredient (API) in preclinical research for potential therapies targeting pain, inflammation, and neurological disorders.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and competitive binding assays to identify and characterize novel receptor modulators.
• Metabolic and Pharmacokinetic Studies: Utilized to study the absorption, distribution, metabolism, and excretion (ADME) profiles of synthetic cannabinoids.
• Forensic Analysis: Acts as a certified reference material (CRM) for the identification and quantification of synthetic cannabinoids in forensic and toxicology laboratories.

Basic Information

Product Name	(6Ar,10Ar)-3-(6-Imidazol-1-Yl-2-Methylhexan-2-Yl)-6,6,9-Trimethyl-6A,7,10,10A-Tetrahydrobenzo[C]Chromen-1-Ol:Hydrochloride
CAS No.	874745-43-4
Molecular Formula	C27H37N3O2·HCl
Molecular Weight	472.07 g/mol (free base: 435.60 g/mol)
Synonyms	JWH-018 N-(5-Hydroxypentyl) analog hydrochloride; 1-Pentyl-3-(1-naphthoyl)indole hydroxy metabolite analog; 3-[(1-(5-Hydroxypentyl)-1H-indol-3-yl)carbonyl]-1-naphthalenol hydrochloride; JWH-018 5-Hydroxypentyl metabolite HCl; JWH-018 5-OH analog hydrochloride; AM-2201 5-Hydroxypentyl metabolite HCl; Synthetic Cannabinoid Receptor Agonist Metabolite Standard
EINECS	Contact for details

Quality Control

Our production of (6Ar,10Ar)-3-(6-Imidazol-1-Yl-2-Methylhexan-2-Yl)-6,6,9-Trimethyl-6A,7,10,10A-Tetrahydrobenzo[C]Chromen-1-Ol:Hydrochloride adheres to stringent quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting critical specifications. Our quality commitment supports compliance with GLP (Good Laboratory Practice) standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a cool, dry, and dark place. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.