Description

L-α-Methylleucine Methyl Ester Hydrochloride is a high-purity, non-proteinogenic amino acid derivative used as a critical chiral building block in advanced organic synthesis. Its value lies in providing a sterically hindered, protected leucine analog that is essential for constructing complex peptide mimetics and pharmaceutical intermediates. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, peptidomimetics, and other bioactive molecules.
• Peptide Chemistry Research: Used to introduce steric bulk and modify backbone properties in custom peptide sequences for structure-activity relationship (SAR) studies.
• Agrochemical Development: Serves as a building block for creating novel chiral active ingredients with specific biological activity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective catalytic reactions to construct complex molecular architectures.
• Bioconjugation & Labeling: The ester and protected amine functionalities allow for selective modification and linker attachment in bioconjugate chemistry.
• Academic & Industrial R&D: Fundamental research tool in medicinal chemistry and chemical biology for exploring new therapeutic modalities.

Basic Information

Product Name	L-α-Methylleucine Methyl Ester Hydrochloride
CAS No.	873924-30-2
Molecular Formula	C8H18ClNO2
Molecular Weight	195.69 g/mol
Synonyms	L-α-Methylleucine Methyl Ester HCl; (S)-2-Amino-4-methyl-2-methylpentanoic Acid Methyl Ester Hydrochloride; Methyl (2S)-2-amino-4-methyl-2-methylpentanoate hydrochloride; Methyl L-α-methylleucinate hydrochloride; (S)-2-Amino-2,4-dimethylpentanoic Acid Methyl Ester Hydrochloride; L-2-Amino-4-methyl-2-methylvaleric Acid Methyl Ester Hydrochloride; α-Methyl-L-leucine Methyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our L-α-Methylleucine Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and compliance with customer specifications. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and other critical parameters are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccant or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.