Description

1H-1-Benzazepine-1-Carboxylic Acid, 2,3,4,5-Tetrahydro-5-Hydroxy-7-Methyl-8-(Trifluoromethyl)-, 1,1-Dimethylethyl Ester, (5R)- is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is of significant commercial interest for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development and scale-up of novel drug candidates, especially within the central nervous system (CNS) and metabolic disorder pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of proprietary drug substances targeting specific biological pathways.
• Active Pharmaceutical Ingredient (API) Development: Serves as a critical precursor in the research and process development of new chemical entities (NCEs).
• Preclinical & Clinical Research: Used to produce materials for pharmacological studies, toxicology assessments, and early-phase clinical trials.
• Process Chemistry & Scale-Up: Essential for optimizing synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control.

Basic Information

Product Name	1H-1-Benzazepine-1-Carboxylic Acid, 2,3,4,5-Tetrahydro-5-Hydroxy-7-Methyl-8-(Trifluoromethyl)-, 1,1-Dimethylethyl Ester, (5R)-
CAS No.	872624-60-7
Molecular Formula	C₁₈H₂₂F₃NO₃
Molecular Weight	357.37 g/mol
Synonyms	(5R)-5-Hydroxy-7-methyl-8-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carboxylic acid tert-butyl ester; tert-Butyl (5R)-5-hydroxy-7-methyl-8-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carboxylate; (R)-tert-Butyl 5-hydroxy-7-methyl-8-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate; (5R)-Benzazepine tert-butyl ester derivative; UNII-Contact for details; 1-BOC-5R-hydroxy-7-methyl-8-CF3-2,3,4,5-tetrahydro-1H-1-benzazepine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and MS to confirm identity, purity, and chiral integrity. A Certificate of Analysis (COA) detailing all specified parameters is provided with each shipment. We support compliance with cGMP guidelines for pharmaceutical intermediates, and specifications can be aligned with client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants and maintaining an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (5R)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.