Description

4(1)-Quinolone, 3-Chloro-5-Methyl-1-p-Tolylsulfonyl- (2Ci) is a specialized sulfonamide-protected quinolone derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. Its core value lies in providing a reactive scaffold for constructing complex nitrogen-containing heterocycles, which are pivotal in modern pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel quinolone-based antibiotics and other bioactive molecules targeting bacterial DNA gyrase and topoisomerase IV.
• Agrochemical Research: Used in the development of new fungicides and herbicides, leveraging the quinolone core's biological activity.
• Organic Synthesis Scaffold: The p-tolylsulfonyl protecting group and halogenated structure make it a versatile precursor for further functionalization via cross-coupling, nucleophilic substitution, and cyclization reactions.
• Material Science Research: Potential intermediate in the synthesis of organic semiconductors or ligands for catalytic systems due to its conjugated heterocyclic system.
• Academic & Contract Research: A valuable reagent for methodological studies in heterocyclic chemistry and medicinal chemistry programs within universities and CROs.

Basic Information

Product Name	4(1)-Quinolone, 3-Chloro-5-Methyl-1-p-Tolylsulfonyl- (2Ci)
CAS No.	871890-91-4
Molecular Formula	C17H14ClNO3S
Molecular Weight	347.81 g/mol
Synonyms	3-Chloro-5-methyl-1-[(4-methylphenyl)sulfonyl]-4(1H)-quinolone; 1-(4-Methylbenzenesulfonyl)-3-chloro-5-methylquinolin-4(1H)-one; 3-Chloro-5-methyl-1-tosyl-4(1H)-quinolone; 3-Chloro-5-methyl-1-(p-tolylsulfonyl)-4(1H)-quinolone; 1-Tosyl-3-chloro-5-methyl-4-quinolone; 4(1H)-Quinolone, 3-chloro-5-methyl-1-[(4-methylphenyl)sulfonyl]-; 871890-91-4
EINECS	Contact for details

Quality Control

Our 4(1)-Quinolone, 3-Chloro-5-Methyl-1-p-Tolylsulfonyl- (2Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.