Description

4-(7-Hydroxy-2-Isopropyl-4-Oxoquinazolin-3(4H)-Yl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate with a distinct quinazolinone core structure. This compound is valued for its role as a critical building block in the synthesis of novel, targeted therapeutic agents, offering researchers and manufacturers a reliable and well-characterized starting material. It is primarily utilized by pharmaceutical R&D teams and fine chemical producers engaged in developing innovative small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), especially kinase inhibitors and other targeted therapies.
• Oncology Drug Discovery: Serves as a core scaffold for constructing novel compounds with potential anti-cancer activity in preclinical and clinical research.
• Biochemical Research: Used as a reference standard or probe molecule in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for constructing complex heterocyclic molecules in academic and industrial laboratories.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of investigational and commercial drugs.

Basic Information

Product Name	4-(7-Hydroxy-2-Isopropyl-4-Oxoquinazolin-3(4H)-Yl)Benzonitrile
CAS No.	871814-52-7
Molecular Formula	C18H15N3O2
Molecular Weight	305.33 g/mol
Synonyms	4-(7-Hydroxy-2-isopropyl-4-oxo-3,4-dihydroquinazolin-3-yl)benzonitrile; 3-(4-Cyanophenyl)-7-hydroxy-2-(propan-2-yl)quinazolin-4(3H)-one; 871814-52-7; 4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3-yl)benzonitrile; Quinazolinone benzonitrile derivative
EINECS	Contact for details

Quality Control

Our production of 4-(7-Hydroxy-2-Isopropyl-4-Oxoquinazolin-3(4H)-Yl)Benzonitrile adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.