Description

6-tert-Butyl 1-Methyl 6-Azaspiro[2.5]Octane-1,6-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. It is essential for medicinal chemistry R&D and process development teams in pharmaceutical and biotechnology companies seeking to develop new therapeutic entities.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to explore new chemical spaces.
• Process Chemistry Development: Serves as a standardized building block for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic & Contract Research: Employed in university and CRO laboratories for the discovery of new bioactive molecules and pharmacological tools.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use as a component in the linker or warhead design of bifunctional degraders.

Basic Information

Product Name	6-tert-Butyl 1-Methyl 6-Azaspiro[2.5]Octane-1,6-Dicarboxylate
CAS No.	871727-04-7
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	1,6-Dicarboxylic acid, 6-azaspiro[2.5]octane-1,6-di-, 6-(1,1-dimethylethyl) 1-methyl ester; 6-tert-Butyl 1-methyl 6-azaspiro[2.5]octane-1,6-dicarboxylate; 6-Azaspiro[2.5]octane-1,6-dicarboxylic acid, 6-(1,1-dimethylethyl) 1-methyl ester; Methyl 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylate; 6-Boc-1-methyl 6-azaspiro[2.5]octane-1,6-dicarboxylate; tert-Butyl 1-(methoxycarbonyl)-6-azaspiro[2.5]octane-6-carboxylate
EINECS	Contact for details

Quality Control

Our 6-tert-Butyl 1-Methyl 6-Azaspiro[2.5]Octane-1,6-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.