Description

2-Chloro-5-(6-Methoxy-7-(2-Methoxyethoxy)Quinazolin-4-Ylamino)Cyclohexa-2,5-Diene-1,4-Dione is a high-purity, advanced pharmaceutical intermediate with a complex quinazoline-dione structure. This compound is critical for research and development in targeted oncology therapies, offering a key building block for novel kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and fine chemical manufacturers engaged in the synthesis of next-generation anticancer agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent and selective tyrosine kinase inhibitors (TKIs) for cancer treatment.
• Oncology Drug Discovery: Used in medicinal chemistry research for developing novel small-molecule therapeutics targeting specific cancer pathways.
• Biochemical Research: Serves as a reference standard or active compound in enzymatic assays and biological activity studies.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) under GMP conditions.
• Custom Synthesis: A starting material for the custom manufacturing of specialized analogs and derivatives for client-specific research programs.

Basic Information

Product Name	2-Chloro-5-(6-Methoxy-7-(2-Methoxyethoxy)Quinazolin-4-Ylamino)Cyclohexa-2,5-Diene-1,4-Dione
CAS No.	870959-62-9
Molecular Formula	C20H18ClN3O6
Molecular Weight	431.83 g/mol
Synonyms	2-Chloro-5-[(6-methoxy-7-(2-methoxyethoxy)-4-quinazolinyl)amino]-2,5-cyclohexadiene-1,4-dione; 4-Quinazolinamine, 2-chloro-5-((6-methoxy-7-(2-methoxyethoxy)-4-quinazolinyl)amino)-2,5-cyclohexadiene-1,4-dione; CAS 870959-62-9; Quinazoline-dione intermediate; TKIs Intermediate; Kinase Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and traceability. Certificates of Analysis (COA) are provided with each shipment, detailing purity, identity, and impurity profiles as determined by validated analytical methods including HPLC, NMR, and MS. We support development under quality systems suitable for GMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep the container sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.