Description

(1R,3R,5S)-tert-Butyl 3-Hydroxy-3-Methyl-8-Azabicyclo[3.2.1]Octane-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined bicyclic structure. This compound is a critical chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries who require a reliable source of high-quality, stereochemically pure intermediates.

Application

• Key Chiral Intermediate in the synthesis of Tropane alkaloid derivatives and related pharmaceutical actives.
• Building Block for CNS Drugs, utilized in the research and production of compounds targeting neurological receptors.
• Precursor for Antiviral Agents, serving as a core scaffold in the development of novel therapeutic candidates.
• Process Chemistry & Scale-Up, enabling the transition from laboratory-scale research to commercial manufacturing under GMP guidelines.
• Asymmetric Synthesis, leveraging its defined stereocenters for the construction of complex molecular architectures.
• Reference Standard for analytical method development and quality control in pharmaceutical production.

Basic Information

Product Name	(1R,3R,5S)-tert-Butyl 3-Hydroxy-3-Methyl-8-Azabicyclo[3.2.1]Octane-8-Carboxylate
CAS No.	870889-20-6
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	8-Boc-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octane; (1R,3R,5S)-8-(tert-Butoxycarbonyl)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octane; 3-Hydroxy-3-methyl-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester; 8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-hydroxy-3-methyl-, 1,1-dimethylethyl ester, (1R,3R,5S)-; tert-Butyl (1R,3R,5S)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octane-8-carboxylate
EINECS	Contact for details

Quality Control

Our (1R,3R,5S)-tert-Butyl 3-Hydroxy-3-Methyl-8-Azabicyclo[3.2.1]Octane-8-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for pharmaceutical development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.