Description

(S)-tert-Butyl (1-(5-Fluoro-4-Oxo-3-Phenyl-3,4-Dihydroquinazolin-2-Yl)Propyl)Carbamate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical chiral building block for the synthesis of targeted therapeutic agents, particularly in oncology and other specialized fields. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the creation of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potent, targeted anticancer agents and other bioactive molecules.
• Oncology Drug Development: Central to research programs focused on kinase inhibitors and other mechanisms targeting specific cancer pathways.
• Preclinical & Clinical Research: Used to produce candidate compounds for pharmacological evaluation, toxicology studies, and early-phase clinical trials.
• Process Chemistry & Scale-Up: Serves as a defined starting material for optimizing robust, scalable, and cost-effective manufacturing routes for Active Pharmaceutical Ingredients (APIs).
• Custom Synthesis & Building Blocks: Provides a versatile, structurally complex core for medicinal chemists to explore structure-activity relationships (SAR) and develop new chemical entities.

Basic Information

Product Name	(S)-tert-Butyl (1-(5-Fluoro-4-Oxo-3-Phenyl-3,4-Dihydroquinazolin-2-Yl)Propyl)Carbamate
CAS No.	870281-85-9
Molecular Formula	C22H24FN3O3
Molecular Weight	397.45 g/mol
Synonyms	Boc-Protected 5-Fluoro-3-Phenylquinazolinone Derivative; (S)-tert-Butyl N-[1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate; 2-[(2S)-1-[(tert-Butoxy)carbonylamino]propyl]-5-fluoro-3-phenylquinazolin-4(3H)-one; tert-Butyl ((1S)-1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate; CAS 870281-85-9; 870281-85-9
EINECS	Contact for details

Quality Control

Every batch of (S)-tert-Butyl (1-(5-Fluoro-4-Oxo-3-Phenyl-3,4-Dihydroquinazolin-2-Yl)Propyl)Carbamate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and chiral purity essential for pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.