Description

4-Chloro-6-Hydroxy-2-Trifluoromethyl-Quinazoline is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring a quinazoline core substituted with chloro, hydroxy, and trifluoromethyl groups, makes it a versatile precursor for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of potential drug candidates, particularly kinase inhibitors, anticancer agents, and other biologically active heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group can enhance bioavailability and stability.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes and affinity tags for studying biological systems and protein functions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Chloro-6-Hydroxy-2-Trifluoromethyl-Quinazoline
CAS No.	870137-70-5
Molecular Formula	C9H4ClF3N2O
Molecular Weight	248.59 g/mol
Synonyms	4-Chloro-6-hydroxy-2-(trifluoromethyl)quinazoline; 2-Trifluoromethyl-4-chloro-6-hydroxyquinazoline; 4-Chloro-2-trifluoromethyl-6-quinazolinol; Quinazoline, 4-chloro-6-hydroxy-2-(trifluoromethyl)-; 870137-70-5; 4-Chloro-6-hydroxy-2-trifluoromethylquinazoline; 6-Hydroxy-4-chloro-2-trifluoromethylquinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Hydroxy-2-Trifluoromethyl-Quinazoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.