Description

5-Isoxazolol, 4,5-Dihydro-3-(4-Hydroxyphenyl)-4-Phenyl-5-(Trifluoromethyl)- is a specialized trifluoromethylated isoxazoline derivative, a high-value building block prized for its unique structural features. This compound matters for its role as a key synthetic intermediate in advanced pharmaceutical and agrochemical research, where the trifluoromethyl group and isoxazoline core are critical for modulating biological activity and physicochemical properties. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Acts as a monomer or functional additive in the research of specialty polymers and advanced organic materials.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a molecular scaffold in fragment-based drug discovery.
• Custom Synthesis & Contract Manufacturing: A key starting material for fine chemical suppliers offering bespoke synthesis services to the life sciences industry.

Basic Information

Product Name	5-Isoxazolol, 4,5-Dihydro-3-(4-Hydroxyphenyl)-4-Phenyl-5-(Trifluoromethyl)-
CAS No.	869852-77-7
Molecular Formula	C16H12F3NO2
Molecular Weight	307.27 g/mol
Synonyms	4,5-Dihydro-3-(4-hydroxyphenyl)-4-phenyl-5-(trifluoromethyl)isoxazol-5-ol; 3-(4-Hydroxyphenyl)-4-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazol-5-ol; 5-(Trifluoromethyl)-4,5-dihydro-3-(4'-hydroxyphenyl)-4-phenylisoxazol-5-ol; Trifluoromethyl dihydroisoxazolol derivative; TFMI Building Block
EINECS	Contact for details

Quality Control

Our 5-Isoxazolol derivative is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with full traceability are provided to guarantee batch-to-batch consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.