Description

1-Benzhydryl-3-Fluoro-Azetidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 869488-99-3. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and therapeutic agent research. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those targeting neurological pathways.
• Drug Discovery & Medicinal Chemistry: Used in research and development for creating new chemical entities (NCEs) and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial structural component in the manufacturing process of specific APIs.
• Biochemical Research: Employed in studies investigating enzyme inhibition, receptor binding, and other pharmacological mechanisms.
• Process Chemistry & Scale-Up: Utilized in developing and optimizing scalable synthetic routes for commercial production.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	1-Benzhydryl-3-Fluoro-Azetidine Hydrochloride
CAS No.	869488-99-3
Molecular Formula	C16H17FN•HCl
Molecular Weight	277.77 g/mol (Free base: 242.31 g/mol)
Synonyms	1-(Diphenylmethyl)-3-fluoroazetidine hydrochloride; 3-Fluoro-1-(phenyl(phenyl)methyl)azetidine hydrochloride; 1-(Benzenhydryl)-3-fluoroazetidine HCl; Benzhydryl-3-fluoroazetidine HCl; Azetidine, 3-fluoro-1-(diphenylmethyl)-, hydrochloride; 869488-99-3; 1-(Diphenylmethyl)-3-fluoroazetidine HCl salt
EINECS	Contact for details

Quality Control

Our 1-Benzhydryl-3-Fluoro-Azetidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results from techniques such as HPLC, NMR, and mass spectrometry. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.