Description

trans-3,4-Difluoropyrrolidine Hydrochloride is a high-purity, fluorinated pyrrolidine derivative supplied as a hydrochloride salt. This compound serves as a critical pharmaceutical intermediate and versatile building block in modern organic synthesis, particularly for introducing the difluoropyrrolidine moiety. It is primarily utilized by research institutions and chemical manufacturers in the life sciences sector for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, leveraging the biological activity of the fluorinated pyrrolidine structure.
• Medicinal Chemistry: A valuable scaffold for constructing compound libraries in drug discovery programs, enabling structure-activity relationship (SAR) studies.
• Chemical Biology: Employed as a probe or ligand in the study of enzyme inhibition and receptor binding, due to its specific stereochemistry and fluorine atoms.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scale-up and optimization of synthetic routes for commercial production.

Basic Information

Product Name	trans-3,4-Difluoropyrrolidine Hydrochloride
CAS No.	869481-92-5
Molecular Formula	C4H8F2N·HCl
Molecular Weight	155.57 g/mol (Free base: 119.11 g/mol)
Synonyms	(3R,4S)-3,4-Difluoropyrrolidine Hydrochloride; trans-3,4-Difluoropyrrolidine HCl; (3R,4S)-3,4-Difluoropyrrolidine Hydrochloride; 3,4-Difluoropyrrolidine Hydrochloride (trans); Pyrrolidine, 3,4-difluoro-, hydrochloride, (3R,4S)-; 869481-92-5; 3,4-Difluoropyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our trans-3,4-Difluoropyrrolidine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) documenting identity, purity (HPLC), and impurity profiles are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.