Description

(-)-2,3-Bis[(2R,5R)-2,5-Dimethylphospholano]-n-Methylmaleimide(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate is a highly specialized, chiral organorhodium complex primarily employed as a precise and efficient asymmetric hydrogenation catalyst. Its value lies in its ability to induce high enantioselectivity in the synthesis of chiral molecules, which is critical for producing active pharmaceutical ingredients (APIs) and fine chemicals with the correct stereochemistry. This catalyst is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable and reproducible asymmetric transformations.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Pharmaceutical API Manufacturing: Key for producing chiral active pharmaceutical ingredients (APIs) with high optical purity, such as β-amino acids and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables the synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable tool for method development and exploring new asymmetric synthetic pathways in chemistry research.
• Material Science: Potential application in the synthesis of chiral polymers or ligands for advanced materials.

Basic Information

Item	Detail
Product Name	(-)-2,3-Bis[(2R,5R)-2,5-Dimethylphospholano]-n-Methylmaleimide(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate
CAS No.	868851-50-7
Molecular Formula	C₂₅H₄₀BF₄NOP₂Rh
Molecular Weight	622.26 g/mol
Synonyms	(-)-2,3-Bis[(2R,5R)-2,5-dimethylphospholano]-n-methylmaleimide(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; Rhodium(I) (1,5-cyclooctadiene)[(2R,5R)-2,5-dimethylphospholano][(2R,5R)-2,5-dimethylphospholano]maleimide tetrafluoroborate; DuPhos Rhodium Catalyst; (R,R)-Me-DuPhos Rh(COD)BF4; Asymmetric Hydrogenation Catalyst Rh-DuPhos; [Rh((R,R)-Me-DuPhos)(COD)]BF4; Chiral Rhodium Complex; Rh-(R,R)-Me-DuPhos
EINECS	Contact for details

Quality Control

Our (-)-2,3-Bis[(2R,5R)-2,5-Dimethylphospholano]-n-Methylmaleimide(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high catalytic activity, enantiomeric purity, and batch-to-batch consistency. Standard quality parameters include assay by NMR, chiral purity by HPLC, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a freezer. This compound is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be sealed immediately after use to minimize exposure to air and moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (Assay by 31P NMR)	≥ 95%
Chiral Purity (Enantiomeric Excess)	≥ 99% ee
Rhodium Content	~16.5% (Theoretical)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.