Description

(R)-(-)-α-Methylhistamine Dihydrobromide CAS NO 868698-49-1 is a high-purity, enantiomerically pure chemical compound of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block and a potent, selective agonist for histamine H3 receptors, enabling precise pharmacological studies. It is primarily utilized by research institutions, pharmaceutical companies, and contract development organizations engaged in neuroscience, drug discovery, and the synthesis of novel therapeutic agents targeting central nervous system disorders.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control in drug manufacturing.
• Neuroscience Research: A key tool compound for studying the role and function of histamine H3 receptors in the brain, aiding in the understanding of sleep-wake cycles, cognitive function, and appetite regulation.
• Drug Discovery & Development: Employed as a chiral intermediate or a lead compound in the synthesis and optimization of new chemical entities targeting H3 receptors for potential therapeutic applications.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and in vitro pharmacological assays to evaluate receptor binding affinity and functional activity.
• Academic Research: Supports fundamental chemical and biological research in universities and institutes focusing on medicinal chemistry and neuropharmacology.

Basic Information

Product Name	(R)-(-)-α-Methylhistamine Dihydrobromide
CAS No.	868698-49-1
Molecular Formula	C6H14N3·2HBr
Molecular Weight	308.02 g/mol
Synonyms	(R)-(-)-α-Methylhistamine dihydrobromide; (R)-α-Methylhistamine Dihydrobromide; (R)-(-)-2-(1H-Imidazol-4-yl)-1-methyl-ethanamine dihydrobromide; (R)-MHA Dihydrobromide; (R)-(-)-Methylhistamine Dihydrobromide; (R)-H3 Agonist; (R)-(-)-α-MeHA·2HBr; (2R)-2-(1H-imidazol-5-yl)-N-methylethanamine dihydrobromide
EINECS	Contact for details

Quality Control

Every batch of (R)-(-)-α-Methylhistamine Dihydrobromide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), chiral purity, and other critical parameters is provided with each shipment to support your quality and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.