Description

8-Methyl-5-(trifluoromethyl)quinoline is a high-purity, advanced pharmaceutical intermediate and versatile heterocyclic building block. Its core value lies in the unique structural combination of a quinoline scaffold with a trifluoromethyl group, which is critical for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical sectors, particularly for the synthesis of novel active ingredients targeting various disease pathways.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small-molecule drugs, especially in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the synthesis of novel pesticides and herbicides, where the trifluoromethyl group enhances bioactivity and environmental stability.
• Material Science Precursor: Serves as a building block for functionalized ligands in catalysis and for creating advanced organic electronic materials.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a fluorescent tag or probe due to the quinoline core.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocyclic architectures.

Basic Information

Product Name	8-Methyl-5-(Trifluoromethyl)Quinoline
CAS No.	868668-58-0
Molecular Formula	C11H8F3N
Molecular Weight	211.19 g/mol
Synonyms	5-(Trifluoromethyl)-8-methylquinoline; 8-Methyl-5-(trifluoromethyl)quinoline; 8-Methyl-5-trifluoromethylquinoline; Quinoline, 8-methyl-5-(trifluoromethyl)-; 868668-58-0
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical products. 8-Methyl-5-(trifluoromethyl)quinoline is manufactured and analyzed under a quality management system to ensure batch-to-batch consistency and high purity. Comprehensive analytical testing, including HPLC, GC, NMR, and MS, is performed. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/GC-MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.