Description

tert-Butyl 6-Chloro-7-Methyl-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, particularly for central nervous system (CNS) and other targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for drug discovery and development.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries and exploring structure-activity relationships (SAR) in lead optimization programs.
• CNS Drug Development: Its structural features make it particularly relevant for research targeting neurological and psychiatric disorders.
• Process Chemistry & Scale-Up: Supplied to support route scouting, process development, and cGMP manufacturing for clinical trial materials.
• Contract Research & Manufacturing (CRO/CMO): A key raw material for organizations providing custom synthesis and manufacturing services to the biopharma industry.

Basic Information

Product Name	tert-Butyl 6-Chloro-7-Methyl-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate
CAS No.	868361-90-4
Molecular Formula	C19H24ClNO4
Molecular Weight	365.85 g/mol
Synonyms	1'-tert-Butoxycarbonyl-6-chloro-7-methyl-4-oxospiro[chroman-2,4'-piperidine]; 1'-Boc-6-chloro-7-methyl-4-oxospiro[chroman-2,4'-piperidine]; 6-Chloro-7-methyl-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 6-chloro-7-methyl-4-oxospiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylate; Spiro[chroman-2,4'-piperidine]-1'-carboxylic acid, 6-chloro-7-methyl-4-oxo-, 1,1-dimethylethyl ester; CAS 868361-90-4
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. We adhere to strict internal quality protocols to support our customers' research and development needs. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.