Description

Fmoc-4-(3-Aminophenyl)Butanoic Acid CAS NO 867382-45-4 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of a modified phenylalanine side chain, enabling the creation of complex peptides with specific structural and functional properties. It is primarily utilized by pharmaceutical researchers, biotech companies, and CROs engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptide sequences.
• Therapeutic Peptide Development: Used to incorporate a 4-(3-aminophenyl)butanoic acid moiety into peptide backbones for drug discovery targeting GPCRs, enzymes, and other biological targets.
• Peptidomimetic Design: Provides a scaffold for creating non-natural peptide analogs with enhanced stability, bioavailability, and binding affinity.
• Bioconjugation and Linker Chemistry: The carboxylic acid and aromatic amine groups offer handles for conjugation to other molecules, surfaces, or solid supports.
• Chemical Biology Research: Employed in the synthesis of labeled peptides, activity-based probes, and tools for studying protein-protein interactions.
• Material Science: Potential use in the synthesis of peptide-based polymers or biomaterials with specific surface properties.

Basic Information

Product Name	Fmoc-4-(3-Aminophenyl)Butanoic Acid
CAS No.	867382-45-4
Molecular Formula	C25H23NO4
Molecular Weight	401.46 g/mol
Synonyms	Fmoc-4-(3-Aminophenyl)butyric Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(3-aminophenyl)butanoic Acid; 4-(3-Aminophenyl)butanoic Acid, N-Fmoc derivative; Fmoc-APBA; Fmoc-3-Amino-L-homophenylalanine side chain derivative; N-α-Fmoc-4-(3-aminophenyl)butyric Acid; Fmoc-DL-4-(3-Aminophenyl)butanoic Acid (if racemic); 9-Fluorenylmethyl N-[4-(3-aminophenyl)butanoyl]carbamate
EINECS	Contact for details

Quality Control

Our Fmoc-4-(3-Aminophenyl)Butanoic Acid is manufactured under strict quality systems to ensure consistency and reliability for sensitive research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.