Description

4-Bromo-7-Chloro-8-Fluoro-2-Phenylquinoline is a high-purity, multi-halogenated quinoline derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and functional materials, where its unique halogen pattern enables precise structural modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active compounds and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and anticancer agent research.
• Agrochemical Development: Used in the research and production of advanced pesticides and herbicides, leveraging its halogenated quinoline core.
• Material Science Research: Serves as a building block for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex quinoline scaffolds into target molecules.
• Ligand and Catalyst Design: Utilized in the development of novel ligands for transition metal catalysis due to the coordinating potential of the nitrogen atom.
• Fluorescent Probe Synthesis: Acts as a core structure for developing sensitive fluorescent dyes and biological imaging agents.

Basic Information

Product Name	4-Bromo-7-Chloro-8-Fluoro-2-Phenylquinoline
CAS No.	867164-98-5
Molecular Formula	C₁₅H₈BrClFN
Molecular Weight	352.59 g/mol
Synonyms	4-Bromo-7-chloro-8-fluoro-2-phenylquinoline; 2-Phenyl-4-bromo-7-chloro-8-fluoroquinoline; Quinoline, 4-bromo-7-chloro-8-fluoro-2-phenyl-; 867164-98-5; 4-Br-7-Cl-8-F-2-Ph-quinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-7-Chloro-8-Fluoro-2-Phenylquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for your most critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.