Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1R)-2'-(Dimethylamino)[1,1'-Binaphthalen]-2-Yl]- Thiourea is a sophisticated chiral thiourea derivative, recognized as a highly effective organocatalyst and asymmetric synthesis reagent. Its core value lies in its ability to facilitate enantioselective transformations with high selectivity and yield, making it indispensable for advanced chemical synthesis. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers focused on developing novel active ingredients and high-value intermediates.

Application

• Asymmetric Organocatalysis: Employed as a chiral hydrogen-bond donor catalyst for enantioselective reactions such as Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: A key building block and chiral auxiliary in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Chiral Resolution Agent: Used in the separation and purification of enantiomers via diastereomeric salt formation or chiral stationary phase development.
• Ligand for Metal Complexes: Serves as a precursor for creating chiral ligands used in transition metal-catalyzed asymmetric synthesis.
• Material Science Research: Investigated for the development of chiral functional materials and sensors due to its unique binaphthyl scaffold and hydrogen-bonding capability.

Basic Information

Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1R)-2'-(Dimethylamino)[1,1'-Binaphthalen]-2-Yl]- Thiourea
CAS No.	866940-63-8
Molecular Formula	C₃₂H₂₄F₆N₄S
Molecular Weight	610.62 g/mol
Synonyms	(R)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-{2-[2-(dimethylamino)-1-naphthyl]-1-naphthyl}thiourea; (R)-DTB-Thiourea; (R)-3,5-Bis(trifluoromethyl)phenyl(2'-(dimethylamino)-[1,1'-binaphthalen]-2-yl)thiourea; Chiral Thiourea Organocatalyst; (R)-BINAM-Thiourea Derivative; N-(3,5-Bis(trifluoromethyl)phenyl)-N'-((R)-2'-(dimethylamino)-[1,1'-binaphthalen]-2-yl)thiourea; Asymmetric Thiourea Catalyst
EINECS	Contact for details

Quality Control

Our production of this high-value chiral chemical adheres to stringent quality assurance protocols. Every batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet the exacting standards required for research and process development. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and chiral analysis. We support compliance with REACH and other global regulatory frameworks upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.