Description

(7R,8S)-8-(3,4-Dimethoxyphenyl)-8-(2-Propen-1-Yl)-1,4-Dioxaspiro[4.5]Decan-7-Ol is a sophisticated chiral intermediate of significant importance in modern synthetic organic chemistry. Its value lies in its complex spirocyclic and dioxolane-protected diol structure, which serves as a versatile building block for the stereoselective synthesis of complex molecules. This compound is primarily needed by research and development teams in the pharmaceutical and fine chemical industries for the development of new active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug discovery programs.
• Asymmetric Synthesis: Utilized as a critical building block in stereocontrolled chemical reactions to introduce specific three-dimensional architecture into target molecules.
• Natural Product Synthesis: Serves as a precursor or intermediate in the total synthesis of complex natural products with spirocyclic or polycyclic frameworks.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale for potential commercial manufacturing of advanced intermediates.
• Catalyst and Ligand Research: Can be employed in the development of novel chiral catalysts or ligands for enantioselective transformations.
• Academic and Industrial R&D: A valuable compound for methodological studies in organic synthesis within university laboratories and corporate R&D facilities.

Basic Information

Product Name	(7R,8S)-8-(3,4-Dimethoxyphenyl)-8-(2-Propen-1-Yl)-1,4-Dioxaspiro[4.5]Decan-7-Ol
CAS No.	866394-48-1
Molecular Formula	C20H28O5
Molecular Weight	348.43 g/mol
Synonyms	(7R,8S)-8-(3,4-Dimethoxyphenyl)-8-(allyl)-1,4-dioxaspiro[4.5]decan-7-ol; (7R,8S)-8-Allyl-8-(3,4-dimethoxyphenyl)-1,4-dioxaspiro[4.5]decan-7-ol; 1,4-Dioxaspiro[4.5]decan-7-ol, 8-(3,4-dimethoxyphenyl)-8-(2-propen-1-yl)-, (7R,8S)-; Spirocyclic Dioxolane Allylphenol Intermediate; CAS 866394-48-1
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, chiral HPLC, GC, NMR, and IR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, enantiomeric excess, and impurity profiles. Our quality systems are designed to support cGMP requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.