Description

4-[(4-Bromophenyl)Sulfonyl]-1-Oxa-4-Azaspiro[4.5]Decane is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and sulfonyl-bridged biphenyl structure. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by R&D chemists and process development scientists in the global pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates targeting neurological disorders.
• Organic Synthesis Building Block: Used in Suzuki coupling, Buchwald-Hartwig amination, and other cross-coupling reactions to introduce the 4-bromophenylsulfonyl moiety.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Process Chemistry & Scale-Up: Serves as a starting material for the GMP-compliant production of clinical trial materials.
• Ligand & Catalyst Development: Potential utility in designing novel ligands for asymmetric catalysis due to its rigid spirocyclic framework.

Basic Information

Product Name	4-[(4-Bromophenyl)Sulfonyl]-1-Oxa-4-Azaspiro[4.5]Decane
CAS No.	866155-26-2
Molecular Formula	C15H20BrNO3S
Molecular Weight	374.29 g/mol
Synonyms	1-Oxa-4-azaspiro[4.5]decane, 4-[(4-bromophenyl)sulfonyl]-; 4-(4-Bromobenzenesulfonyl)-1-oxa-4-azaspiro[4.5]decane; 4-(p-Bromophenylsulfonyl)-1-oxa-4-azaspiro[4.5]decane; 4-Bromophenyl 1-oxa-4-azaspiro[4.5]dec-4-yl sulfone; Spirocyclic Sulfone Intermediate; BPD Sulfone Derivative
EINECS	Contact for details

Quality Control

Our production of 4-[(4-Bromophenyl)Sulfonyl]-1-Oxa-4-Azaspiro[4.5]Decane adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP and ISO standards for pharmaceutical intermediates, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.